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取自雄性和雌性大鼠的血管平滑肌细胞原代培养物增殖的差异。

Differences in proliferation of primary cultures of vascular smooth muscle cells taken from male and female rats.

作者信息

Travo P, Barrett G, Burnstock G

出版信息

Blood Vessels. 1980;17(2):110-6. doi: 10.1159/000158240.

DOI:10.1159/000158240
PMID:7362876
Abstract

Vascular smooth muscle cells from thoracic aortas of 10-week-old rats were cultured on different substrates. Cells taken from male animals proliferated more quickly than those taken from females; this was true for all substrates, but the difference was accentuated by growth on collagen membranes. The relationship between these results and the sex-linked incidence of hypertension and atherosclerosis is discussed and a model for future studies proposed.

摘要

从10周龄大鼠胸主动脉获取的血管平滑肌细胞在不同基质上培养。取自雄性动物的细胞比取自雌性动物的细胞增殖更快；在所有基质上均如此，但在胶原膜上生长时这种差异更为明显。讨论了这些结果与高血压和动脉粥样硬化的性别关联发病率之间的关系，并提出了一个未来研究的模型。

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