Davis H H, Siegel B A, Sherman L A, Heaton W A, Naidich T P, Joist J H, Welch M J
Circulation. 1980 May;61(5):982-8. doi: 10.1161/01.cir.61.5.982.
Using autologous platelets labeled with indium-111-oxine, we studied the localization of platelets on arterial lesions by radionuclide scintigraphy in 34 patients with suspected cerebrovascular disease. The imaging results were compared with the findings of contrast angiography in 23 patients, 16 of whom were receiving antiplatelet and/or anticoagulant drugs during the platelet imaging study. Angiography demonstrated atherosclerotic lesions at 33 sites in the extracranial arteries of 16 of these patients. There was accumulation of 111In-platelets at 20 of these sites (61%) and at three other sites without definite angiographic abnormalities. Lesions with stenoses less than 50% were slightly more frequent than those with greater stenosis (68% vs 45%). The frequency of true-positive scintigraphic results was slightly higher in patients not treated with antithrombotic agents than in those on such drugs (70% vs 57%). Our results suggest that imaging with 111In-labeled autologous platelets may be useful for evaluating the pathophysiologic characteristics of atherosclerotic lesions in patients with cerebrovascular disease.
我们使用铟 - 111 - 奥克辛标记的自体血小板，通过放射性核素闪烁扫描术研究了34例疑似脑血管疾病患者动脉病变处血小板的定位情况。将23例患者的成像结果与血管造影结果进行了比较，其中16例患者在血小板成像研究期间正在接受抗血小板和/或抗凝药物治疗。血管造影显示，这些患者中有16例的颅外动脉33个部位存在动脉粥样硬化病变。在其中20个部位（61%）以及另外3个无明确血管造影异常的部位有111In标记血小板的聚集。狭窄程度小于50%的病变比狭窄程度更大的病变略为常见（68%对45%）。未接受抗血栓药物治疗的患者中，闪烁扫描结果真阳性的频率略高于接受此类药物治疗的患者（70%对57%）。我们的结果表明，用111In标记的自体血小板进行成像可能有助于评估脑血管疾病患者动脉粥样硬化病变的病理生理特征。
