Stern R C, Boat T F, Orenstein D M, Wood R E, Matthews L W, Doershuk C F
Am Rev Respir Dis. 1978 Nov;118(5):821-6. doi: 10.1164/arrd.1978.118.5.821.
Lobar atelectasis occurred in 30 (4.1 per cent) and segmental atelectasis occurred in 6 (0.8 per cent) of 728 patients with cystic fibrosis. The right lung was involved in all 11 patients less than 5 years of age and in 18 of 26 episodes in 19 older patients. Five of the younger patients died within 5 years of the initial episode. Bronchoscopy (with or without local lavage) performed in addition to intensified medical therapy did not appear to improve the outcome. Future studies of therapeutic measures (including bronchoscopy) for treatment of atelectasis complicating cystic fibrosis must include appropriate control patients who receive only medical therapy.
在728例囊性纤维化患者中，30例（4.1%）发生肺叶性肺不张，6例（0.8%）发生节段性肺不张。所有11例5岁以下患者及19例年龄较大患者中的26次发作中的18次，病变累及右肺。5例较年轻患者在首次发作后5年内死亡。除强化药物治疗外进行的支气管镜检查（无论是否进行局部灌洗）似乎并未改善预后。未来针对囊性纤维化合并肺不张治疗措施（包括支气管镜检查）的研究必须纳入仅接受药物治疗的合适对照患者。
