Goulton J, Baker P G
Curr Med Res Opin. 1980;6(6):423-30. doi: 10.1185/03007998009109462.
An open multi-centre study was carried out in general practice to assess the effectiveness and tolerance of ketoprofen in the treatment of 1997 patients with inflammatory arthritic conditions. Patients were treated with 100 mg ketoprofen twice daily for 4 weeks and subjective assessments were made before and after treatment of the clinical symptoms of pain and/or stiffness. The results showed that ketoprofen produced a statistically significant relief of symptoms in painful joints, regardless of whether these were thought to be affected primarily by rheumatoid or osteoarthritic processes. Joint stiffness also improved in the majority of cases. The side-effects reported related mainly to gastro-intestinal symptoms: there were no cases of overt haemorrhage and no serious adverse reactions.
开展了一项开放性多中心全科医学研究，以评估酮洛芬治疗1997例炎性关节炎患者的有效性和耐受性。患者每日两次服用100mg酮洛芬，持续4周，并在治疗前后对疼痛和/或僵硬的临床症状进行主观评估。结果显示，无论疼痛关节被认为主要受类风湿性关节炎还是骨关节炎过程影响，酮洛芬均能使症状得到统计学上的显著缓解。大多数病例的关节僵硬情况也有所改善。报告的副作用主要与胃肠道症状有关：未出现明显出血病例，也无严重不良反应。
