抗锥虫药物作用：其与化疗后复发的关系。
Trypanostatic drug action: its relation to relapse following chemotherapy.
作者信息
Ercoli N, Iudice G
出版信息
Chemotherapy. 1980;26(3):218-23. doi: 10.1159/000237908.
PMID:7363716
Abstract
Analogies with dose-dependent transient prophylaxis and with delayed take of reinfection in drug-cleared Trypanosoma evansi (T. venezuelense) infected animals indicate that relapse following chemotherapy is induced by the same underlying mechanism, i.e., termination of the trypanostatic effect of residual drug concentrations. Correspondingly, both the complete ('true') prophylaxis and the radical cure without relapse require trypanocidal drug concentrations.
摘要
与剂量依赖性短暂预防以及药物清除后的委内瑞拉伊氏锥虫（T. venezuelense）感染动物再次感染延迟发生的类比表明，化疗后的复发是由相同的潜在机制引起的，即残留药物浓度的锥虫抑制作用终止。相应地，完全（“真正”）预防和无复发的根治都需要杀锥虫药物浓度。
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