Morizono T, Paparella M M
Ann Otol Rhinol Laryngol. 1978 Nov-Dec;87(6 Pt 1):804-14. doi: 10.1177/000348947808700607.
Rabbits were used for the long-term study of auditory function associated with experimental hypertension and hypercholesterolemia. Auditory dysfunction (threshold changes of sound evoked responses) was monitored with an electrode, chronically implanted into the contralateral inferior colliculus. Hypertension was created using the renal encapsulation technique. Auditory function in the hypertension trial demonstrated a dip at higher frequencies as well as improvement at lower frequencies. One gram of cholesterol fed daily for three months was capable of making rabbits atherosclerotic. Cholesterol-fed rabbits showed increasing auditory dysfunction over time at all frequencies. When experimental hypertension was combined with hypercholesterolemia, the auditory changes appeared additive. This work, although in preliminary stages, seems to provide experimental evidence that auditory dysfunction is associated with cholesterol diet.
兔子被用于与实验性高血压和高胆固醇血症相关的听觉功能的长期研究。使用慢性植入对侧下丘的电极监测听觉功能障碍（声音诱发反应的阈值变化）。采用肾包膜技术诱发高血压。高血压试验中的听觉功能在高频处出现下降，在低频处有所改善。每天喂食1克胆固醇，持续三个月，能够使兔子发生动脉粥样硬化。喂食胆固醇的兔子在所有频率下随着时间的推移听觉功能障碍都在增加。当实验性高血压与高胆固醇血症相结合时，听觉变化似乎具有累加性。这项工作虽然处于初步阶段，但似乎提供了实验证据，表明听觉功能障碍与胆固醇饮食有关。
