Saito T, Sato K, Saito H
Arch Otorhinolaryngol. 1986;243(4):242-5. doi: 10.1007/BF00464438.
We sought to clarify whether or not hyperlipoproteinemia induces auditory dysfunction. In so doing, we studied the general states and cochlear pathologies of guinea pigs after the administration of a hyperlipid diet for 3 months. Serum biochemistries indicated marked elevations of cholesterol, high density lipoprotein (HDL)-cholesterol and low density lipoprotein (LDL) levels. An increased auditory threshold varying from 10 to 20 dB was observed in 40% of the guinea pigs using auditory brainstem responses. Histochemical study of the inner ear revealed variations in lipid metabolism and partial disorders of the outer hair cells. Electron microscopic observations showed vacuolar and parenchymal protrusions on the surfaces of the stria vascularis and Corti's organ, and vacuolar degeneration was seen around the capillary vessels of the vascular stria. Our data has shown that the auditory dysfunction present in the inner ear was less marked than were the morphological changes seen. Our findings suggest that other factors besides hyperlipoproteinemia are involved in the development of severe auditory damage.
我们试图阐明高脂蛋白血症是否会诱发听觉功能障碍。为此，我们研究了豚鼠在食用高脂饮食3个月后的一般状况和耳蜗病理变化。血清生化指标显示胆固醇、高密度脂蛋白（HDL）-胆固醇和低密度脂蛋白（LDL）水平显著升高。使用听觉脑干反应观察到，40%的豚鼠听觉阈值升高了10至20分贝。内耳的组织化学研究显示脂质代谢存在变化，外毛细胞出现部分紊乱。电子显微镜观察显示血管纹和柯蒂氏器表面有液泡和实质突起，血管纹毛细血管周围可见液泡变性。我们的数据表明，内耳出现的听觉功能障碍不如所观察到的形态学变化明显。我们的研究结果表明，除了高脂蛋白血症外，其他因素也参与了严重听觉损伤的发展。
