6-甲基香豆素光接触性皮炎

6-Methylcoumarin photocontact dermatitis.

作者信息

Jackson R T, Nesbitt L T, DeLeo V A

出版信息

J Am Acad Dermatol. 1980 Feb;2(2):124-7. doi: 10.1016/s0190-9622(80)80390-2.

Abstract

Sporadic cases of a severe photocontact dermatitis have appeared in the last few years following use of fruity-smelling suntan preparations and sunlight exposure. We report five such cases in women who developed severe edema and erythema of sun-exposed areas shortly after application of agents containing 6-methylcoumarin used as fragance. Routine photopatch testing was unproductive in reproducing the reaction, but immediate application of 6-methylcoumarin before ultraviolet A (UVA) radiation elicited significant positive results.

摘要

在过去几年中，使用有水果香味的防晒制剂并暴露于阳光下后，出现了散发性严重光接触性皮炎病例。我们报告了五例这样的病例，这些女性在使用含6 - 甲基香豆素作为香料的制剂后不久，暴露于阳光下的部位出现了严重水肿和红斑。常规光斑贴试验未能重现该反应，但在紫外线A（UVA）照射前立即应用6 - 甲基香豆素可产生显著阳性结果。