Goette D K, Odom R B
J Am Acad Dermatol. 1980 Mar;2(3):212-6. doi: 10.1016/s0190-9622(80)80007-7.
Forty-one keratoacanthomas (KA) occurring in thirty patients were treated with weekly intralesional injections of 5-fluorouracil (5-FU). Forty lesions cleared after an average of three injections in an average of 3.4 weeks (range, 2 to 6 weeks). This response suggests that intralesional injections of 5-FU are the treatment of choice for KAs.