Weigand W, Hannappel E, Brand K
J Nutr. 1980 Apr;110(4):669-74. doi: 10.1093/jn/110.4.669.
Rats of two different ages (72 and 490 days) were subjected to a 3-day fast and then refed for the same period a high-protein (89%) or high-carbohydrate (99%) diet. This experimental model served to study whether alterations occur in the content of the main lipid components, triacylglycerol, phospholipids and cholesterol in liver. It also examined whether the aging process itself has any effect on the lipid pattern. With the high-protein diet the content of all lipids returned to or nearly to the control level regardless of age. Refeeding the 72-day-old rats the high-carbohydrate diet led to a 2.4-fold overshoot in the triacylglycerol content, while the phospholipids and the cholesterol remained far below their control levels. In the 490-day-old rats the total lipids, phospholipids and cholesterol remained at the starvation level. With aging, the total cholesterol content showed a marked increase of about four-fold when corrected for growth.
对两种不同年龄（72天和490天）的大鼠进行为期3天的禁食，然后在相同时间段内重新喂食高蛋白（89%）或高碳水化合物（99%）饮食。该实验模型用于研究肝脏中主要脂质成分（三酰甘油、磷脂和胆固醇）的含量是否发生变化。它还研究了衰老过程本身是否对脂质模式有任何影响。无论年龄大小，喂食高蛋白饮食时，所有脂质的含量都恢复到或几乎恢复到对照水平。给72天大的大鼠重新喂食高碳水化合物饮食导致三酰甘油含量超调2.4倍，而磷脂和胆固醇仍远低于其对照水平。在490天大的大鼠中，总脂质、磷脂和胆固醇保持在饥饿水平。随着衰老，校正生长后总胆固醇含量显著增加约四倍。
