Nace C S, Szepesi B
J Nutr. 1977 Dec;107(12):2109-12. doi: 10.1093/jn/107.12.2109.
The responses of liver glycogen and glucose-6-phosphate dehydrogenase (G6PD) (EC 1.1.1.49) to a high glucose, adequate protein diet were compared between rats previously starved 2 days, then refed a high protein, carbohydrate-free diet for 2 days, and rats previously fed the high protein diet for 4 days. Glycogen levels increased dramatically during the first day the high carbohydrate diet was fed, then decreased gradually on the second day. The response was the same regardless of whether the rats had been starved more before the high protein diet was fed. Liver G6PD activity also increased when the high carbohydrate diet was fed, and continued to increase on the second day. The increase in G6PD, however, was significantly greater in the rats which had been starved before the high protein diet was fed. It is suggested that some process occurs during starvation that predisposes the induction of G6PD upon refeeding a high carbohydrate diet, over and above any effect of glycogen accumulation and breakdown. Glucose or glucose-6-phosphate derived from glycogen does not appear to be the primary inducer of G6PD in rat liver.
将先前饥饿2天，然后再喂2天高蛋白质、无碳水化合物饮食的大鼠，与先前喂4天高蛋白质饮食的大鼠进行比较，观察它们的肝糖原和葡萄糖-6-磷酸脱氢酶（G6PD）（EC 1.1.1.49）对高糖、充足蛋白质饮食的反应。在开始喂高碳水化合物饮食的第一天，糖原水平急剧上升，然后在第二天逐渐下降。无论大鼠在喂高蛋白饮食之前是否经历过更长时间的饥饿，反应都是相同的。喂食高碳水化合物饮食时，肝G6PD活性也会增加，并在第二天持续增加。然而，在高蛋白饮食前经历过饥饿的大鼠中，G6PD的增加明显更大。这表明在饥饿期间发生了一些过程，使得在重新喂食高碳水化合物饮食时，除了糖原积累和分解的任何影响之外，还更容易诱导G6PD。糖原衍生的葡萄糖或葡萄糖-6-磷酸似乎不是大鼠肝脏中G6PD的主要诱导物。
