Behrens W A, Madère R
J Nutr. 1980 Apr;110(4):720-4. doi: 10.1093/jn/110.4.720.
The effect of high dietary ascorbic acid intake on the homeostasis of ascorbic acid and on the metabolism of catecholamine was studied in rats. In order to eliminate changes in serum levels due to stress, blood was obtained without anesthesia through implanted cannulas. Rats with a high intake of ascorbic acid (20 g/kg diet, for 7-9 weeks) had significantly higher levels of ascorbic acid in serum (83%), liver (28%), kidney (47%) and superior cervical ganglia (43%). The values were slightly, but not significantly higher in adrenal gland, brain and interscapular brown adipose tissue. However, no significant differences were observed in the levels of noradrenalin, adrenalin and dopamine in any of the tissues analyzed. Dopamine beta-hydroxylase activity was also unchanged. There was thus no evidence of an effect of high dietary intakes of ascorbic acid on the metabolism of catecholamines in the intact rat.
在大鼠中研究了高剂量膳食摄入抗坏血酸对其抗坏血酸稳态及儿茶酚胺代谢的影响。为消除应激导致的血清水平变化，通过植入插管在无麻醉情况下采集血液。高剂量摄入抗坏血酸（20 g/kg 饲料，持续7 - 9周）的大鼠血清（83%）、肝脏（28%）、肾脏（47%）和颈上神经节（43%）中的抗坏血酸水平显著更高。肾上腺、脑和肩胛间棕色脂肪组织中的数值略高，但无显著差异。然而，在所分析的任何组织中，去甲肾上腺素、肾上腺素和多巴胺水平均未观察到显著差异。多巴胺β - 羟化酶活性也未改变。因此，没有证据表明高剂量膳食摄入抗坏血酸会对完整大鼠的儿茶酚胺代谢产生影响。
