Mulligan J C, Painter M J, O'Donoghue P A, MacDonald H M, Allan A C, Taylor P M
J Pediatr. 1980 May;96(5):903-7. doi: 10.1016/s0022-3476(80)80575-0.
Neonatal asphyxia, defined in this study as delay of greater than 1 minute in onset of spontaneous respiration at birth, occurred in 1% of 13,221 live-born infants of birth weight greater than 500 gm between 1970 and 1971. Seventy-five (56%) of 133 asphyxiated infants survived the neonatal period. Survival was directly related to gestational age. The 65 survivors of asphyxia available for study were seen at a mean age of 4.8 years to determine the incidence and extent of neurologic and developmental abnormalities. Twelve children (18.5%) had severe impairment: nine had both neurologic and intellectual handicaps, two had neurologic impairment alone, and one had intellectual impairment alone. The incidence and severity of impairment were not related to gestational age. Postasphyctic seizures were associated with poor outcome.
本研究将新生儿窒息定义为出生时自发呼吸开始延迟超过1分钟，在1970年至1971年间出生体重超过500克的13221例活产婴儿中，新生儿窒息发生率为1%。133例窒息婴儿中有75例（56%）存活至新生儿期。存活率与胎龄直接相关。对65例可供研究的窒息幸存者进行了观察，平均年龄为4.8岁，以确定神经和发育异常的发生率及程度。12名儿童（18.5%）有严重损伤：9名儿童同时存在神经和智力障碍，2名儿童仅有神经损伤，1名儿童仅有智力损伤。损伤的发生率和严重程度与胎龄无关。窒息后癫痫发作与不良预后相关。
