苯琥胺亚硝基脲衍生物的合成及其抗癌活性
Synthesis and anticancer activity of nitrosourea derivatives of phensuximide.
作者信息
Crider A M, Kolczynski T M, Yates K M
出版信息
J Med Chem. 1980 Mar;23(3):324-6. doi: 10.1021/jm00177a024.
PMID:7365750
Abstract
Nitrosourea derivatives 9--13 which utilize phensuximide (1) as the carrier were synthesized as potential central nervous system antitumor agents. The N-(2-chloroethyl)-N-nitrosourea 13 was active in the mouse ependymoblastoma brain-tumor system, as well as the intraperitoneal L1210 leukemia system.
摘要
以苯琥胺（1）为载体的亚硝基脲衍生物9 - 13被合成为潜在的中枢神经系统抗肿瘤药物。N -（2 - 氯乙基）- N - 亚硝基脲13在小鼠室管膜母细胞瘤脑肿瘤系统以及腹腔注射L1210白血病系统中具有活性。
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