Synthesis and anticancer activity of nitrosourea derivatives of phensuximide.
作者信息
Crider A M, Kolczynski T M, Yates K M
出版信息
J Med Chem. 1980 Mar;23(3):324-6. doi: 10.1021/jm00177a024.
PMID:7365750
Abstract
Nitrosourea derivatives 9--13 which utilize phensuximide (1) as the carrier were synthesized as potential central nervous system antitumor agents. The N-(2-chloroethyl)-N-nitrosourea 13 was active in the mouse ependymoblastoma brain-tumor system, as well as the intraperitoneal L1210 leukemia system.
摘要
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