某些15-氧杂雌甾烷的合成与生物活性
Synthesis and biological activity of some 15-oxaestranes.
作者信息
Rosen P, Boris A, Oliva G
出版信息
J Med Chem. 1980 Mar;23(3):329-30. doi: 10.1021/jm00177a026.
PMID:7365751
Abstract
The estrogenic activity of orally administered 15-oxaestrone was evaluated by the uterotropic assay in rats and was found to be 12 times greater than that of estrone. In addition, several analogues of 15-oxaestrone were prepared and their estrogenic potency was determined.
摘要
通过大鼠子宫增重试验评估了口服15-氧杂雌酮的雌激素活性，发现其活性比雌酮高12倍。此外，还制备了几种15-氧杂雌酮的类似物，并测定了它们的雌激素效价。
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