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[11-氮杂甾体。V. 11-氮杂雌甾烷的激素特性]

[11-azasteroids. V. Hormonal properties of 11-azaestranes].

作者信息

Ivanenko T I, Pivnitskiĭ K K, Fedotov V P

出版信息

Probl Endokrinol (Mosk). 1979 Jan-Feb;25(1):62-8.

PMID:419093
Abstract

Experiments were conducted on sexually-immature female rats, ovariectomized mice and castrated male rats. Hormonal properties of some 11-azaestran were studied. As shown, introduction of azafunction into the position of the 11 molecule of the steroid sharply reduced the hormonal activity, irrespective of other functions in the molecule determining the reference of the steroid to the estron, estradiol, or 19-nortestosterone series.

摘要

对未性成熟的雌性大鼠、去卵巢小鼠和阉割后的雄性大鼠进行了实验。研究了一些11-氮杂雌甾烷的激素特性。结果表明,在甾体分子的11位引入氮杂功能会大幅降低激素活性,而与分子中决定该甾体属于雌酮、雌二醇或19-去甲睾酮系列的其他功能无关。

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