11号染色体小的臂间倒位的高分辨率分析
High resolution of a small pericentric inversion of chromosome 11.
作者信息
Autio-Harmainen H, De La Chapelle A
出版信息
J Med Genet. 1980 Feb;17(1):44-7. doi: 10.1136/jmg.17.1.44.
Abstract
A pericentric inversion 11 (p11q13.3) segragating in two generations is described. A high degree of resolution of the inversion was achieved by using prophase and prometaphase chromosomes from methotrexate-synchronised cells. The inversion occurred in a mother and three of her ten children. It had no detectable clinical consequences.
摘要
描述了一个在两代人中分离的11号染色体臂间倒位（p11q13.3）。通过使用来自甲氨蝶呤同步化细胞的前期和前中期染色体，实现了该倒位的高分辨率。该倒位发生在一位母亲及其十个孩子中的三个身上。它没有可检测到的临床后果。
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