Yunis J J, Sawyer J R, Ball D W
Chromosoma. 1978 Aug 14;67(4):293-307. doi: 10.1007/BF00285963.
The detailed characterization of G-banding patterns of high resolution human chromosomes has been possible with the utilization of a refined cell synchronization technique which routinely yields a large number of excellent quality cells in late prophase, prometaphase, early metaphase, and mid-metaphase. The mitotic cells exhibit up to a 400% increase in the number of bands previously visualized by standard methods. From studies of the banding patterns, it has become evident that the G-positive and, to some extent, the G-negative bands of mid-metaphase results from a coalescence of finer subbands of earlier stages and that each band and its corresponding subbands maintain a constant location throughout the process of chromosome condensation. A precise schematic representation of the number, position, height and staining intensity of bands is presented for the five largest chromosomes of the complement at the four mitotic stages.
利用一种精细的细胞同步技术，已能够详细表征高分辨率人类染色体的G带模式。该技术常规可产生大量处于晚前期、前中期、早中期和中期的优质细胞。有丝分裂细胞的带纹数量比以前用标准方法观察到的增加了高达400%。通过对带纹模式的研究，已明显看出中期的G阳性带以及在一定程度上的G阴性带是由早期更精细的亚带合并而成，并且每个带及其相应的亚带在染色体浓缩过程中保持恒定位置。本文给出了在四个有丝分裂阶段互补组中五条最大染色体的带纹数量、位置、高度和染色强度的精确示意图。
