Alberts D S, Lynch P
Arch Dermatol. 1978 Dec;114(12):1784-7.
Solitary cutaneous plasmacytomas may occur as benign tumors that are confined to the skin, whereas multiple lesions are generally associated with systemic plasma cell disease. Cutaneous plasmacytomas developed in two patients with documented multiple myeloma; this development occurred late in the course of their disease at a time when their systemic plasma cell tumor burden was large-approximately 3 kg in mass, which represented 2 to 3 x 10(12) cells. The occurrence of cutaneous plasmacytomas in patients with multiple myeloma is generally late in the course of the disease and should be considered as a bad prognostic sign.
孤立性皮肤浆细胞瘤可能表现为局限于皮肤的良性肿瘤，而多发性损害通常与系统性浆细胞疾病相关。两名确诊为多发性骨髓瘤的患者发生了皮肤浆细胞瘤；这种情况发生在他们病程的晚期，此时他们的系统性浆细胞肿瘤负荷很大——肿块约3千克，代表2至3×10¹²个细胞。多发性骨髓瘤患者发生皮肤浆细胞瘤通常在病程晚期，应被视为不良预后征象。
