Goldstein R J, Lichtenstein N S, Souder D
JAMA. 1980 May 2;243(17):1737-8.
Sixty-seven thousand seven hundred forty consecutive sets of electrolyte levels measured at the Massachusetts General Hospital were reviewed, and their anion gaps were calculated. A low anion gap (less than 8 mEq/L) was found in 304 patients (0.8%). Repeatedly low anion gaps were found in only 19 patients. Eight patients were hypoalbuminemic, and eight were hyponatremic. For the entire population, there was a positive correlation between sodium concentration and anion gap. The average anion gap was 16.25 mEq/L. The most common cause of a low anion gap was presumptive laboratory error.
对在麻省总医院连续测量的67740组电解质水平进行了回顾，并计算了它们的阴离子间隙。在304名患者（0.8%）中发现了低阴离子间隙（低于8 mEq/L）。仅在19名患者中发现反复出现低阴离子间隙。8名患者为低白蛋白血症，8名患者为低钠血症。对于整个人群，钠浓度与阴离子间隙之间存在正相关。平均阴离子间隙为16.25 mEq/L。低阴离子间隙最常见的原因据推测是实验室误差。
