Gumprecht T, O'Connor D T, Rearden A, Wolf P L
Clin Chem. 1976 Nov;22(11):1920-1.
A young patient with multiple myeloma was found to have a negative anion gap, with marked asymptomatic hyponatremia. The cause for his negative anion gap is thought to be the myeloma protein, which acts as a cation at physiological pH. Such a hyponatremia responds to reduction in serum concentration of paraprotein and should not be treated by sodium replacement.
一名患有多发性骨髓瘤的年轻患者被发现存在阴离子间隙负值，并伴有明显的无症状性低钠血症。其阴离子间隙负值的原因被认为是骨髓瘤蛋白，该蛋白在生理pH值下作为阳离子起作用。这种低钠血症可通过降低副蛋白的血清浓度得到缓解，不应通过补充钠来治疗。
