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Inhibition of mitochondrial carnitine palmitoyl transferase by 2-tetradecylglycidic acid (McN-3802) (preliminary communication).

作者信息

Tutwiler G F, Ryzlak M T

出版信息

Life Sci. 1980 Feb 4;26(5):393-7. doi: 10.1016/0024-3205(80)90156-3.

DOI:10.1016/0024-3205(80)90156-3
PMID:7366330
Abstract
摘要

相似文献

1
Inhibition of mitochondrial carnitine palmitoyl transferase by 2-tetradecylglycidic acid (McN-3802) (preliminary communication).2-十四烷基缩水甘油酸（McN-3802）对线粒体肉碱棕榈酰转移酶的抑制作用（初步报告）
Life Sci. 1980 Feb 4;26(5):393-7. doi: 10.1016/0024-3205(80)90156-3.
2
Action in vivo and in vitro of 2-tetradecylglycidic acid, 2-tetradecylglycidyl-CoA and 2-tetradecylglycidylcarnitine on hepatic carnitine palmitoyltransferase.2-十四烷基缩水甘油酸、2-十四烷基缩水甘油辅酶A和2-十四烷基缩水甘油肉碱对肝脏肉碱棕榈酰转移酶的体内外作用
Biochem J. 1986 Sep 15;238(3):801-9. doi: 10.1042/bj2380801.
3
Identification of 2-tetradecylglycidyl coenzyme A as the active form of methyl 2-tetradecylglycidate (methyl palmoxirate) and its characterization as an irreversible, active site-directed inhibitor of carnitine palmitoyltransferase A in isolated rat liver mitochondria.鉴定2-十四烷基缩水甘油辅酶A为2-十四烷基缩水甘油酸甲酯（棕榈缩水甘油酸甲酯）的活性形式，并将其表征为分离的大鼠肝线粒体中肉碱棕榈酰转移酶A的不可逆的、活性位点导向抑制剂。
J Biol Chem. 1984 Aug 10;259(15):9750-5.
4
Inhibition of mitochondrial carnitine palmitoyl transferase A in vivo with methyl 2-tetradecylglycidate (methyl palmoxirate) and its relationship to ketonemia and glycemia.用2-十四烷基缩水甘油酸甲酯（棕榈酰氧肟酸甲酯）体内抑制线粒体肉碱棕榈酰转移酶A及其与酮血症和血糖的关系。
Proc Soc Exp Biol Med. 1985 Feb;178(2):288-96. doi: 10.3181/00379727-178-42012.
5
Alkylglycidic acids: potential new hypoglycemic agents.烷基缩水甘油酸：潜在的新型降血糖药物。
J Med Chem. 1986 Nov;29(11):2184-90. doi: 10.1021/jm00161a009.
6
Effect of inhibition of fatty acid oxidation on neonatal liver carnitine content.脂肪酸氧化抑制对新生儿肝脏肉碱含量的影响。
Biochem J. 1982 Jun 15;204(3):861-3. doi: 10.1042/bj2040861.
7
Action of the oral hypoglycemic agent 2-tetradecylglycidic acid on hepatic fatty acid oxidation and gluconeogenesis.口服降糖药2-十四烷基缩水甘油酸对肝脏脂肪酸氧化和糖异生的作用。
J Biol Chem. 1979 Apr 25;254(8):2935-41.
8
Carnitine palmitoyltransferase I. The site of inhibition of hepatic fatty acid oxidation by malonyl-CoA.肉碱棕榈酰转移酶I。丙二酰辅酶A对肝脏脂肪酸氧化的抑制位点。
J Biol Chem. 1978 Jun 25;253(12):4128-36.
9
A new inhibitor of the long-chain fatty acid transfer across the mitochondrial membrane: 2-(3-methylcinnamylhydrazono)-propionate (BM 42.304).一种新型的长链脂肪酸跨线粒体膜转运抑制剂：2-(3-甲基肉桂酰腙基)丙酸酯（BM 42.304）。
Life Sci. 1985 Jan 7;36(1):63-7. doi: 10.1016/0024-3205(85)90286-3.
10
Activity of carnitine palmitoyltransferase in mitochondrial outer membranes and peroxisomes in digitonin-permeabilized hepatocytes. Selective modulation of mitochondrial enzyme activity by okadaic acid.洋地黄皂苷通透处理的肝细胞线粒体外膜和过氧化物酶体中肉碱棕榈酰转移酶的活性。冈田酸对线粒体酶活性的选择性调节。
Biochem J. 1992 Oct 15;287 ( Pt 2)(Pt 2):487-92. doi: 10.1042/bj2870487.

引用本文的文献

1
Inhibition by etomoxir of rat liver carnitine octanoyltransferase is produced through the co-ordinate interaction with two histidine residues.依托莫昔对大鼠肝脏肉碱辛酰基转移酶的抑制作用是通过与两个组氨酸残基的协同相互作用产生的。
Biochem J. 2000 Oct 15;351 Pt 2(Pt 2):495-502.
2
The effect of methyl palmoxirate on incorporation of [U-14C]palmitate into rat brain.棕榈酰氧甲酯对[U-14C]棕榈酸掺入大鼠脑内的影响。
Neurochem Res. 1994 Sep;19(9):1217-23. doi: 10.1007/BF00965159.
3
Development and regulation of ketogenesis in hepatocytes isolated from newborn rats.
新生大鼠分离肝细胞中酮体生成的发育与调控
Biochem J. 1983 Sep 15;214(3):937-42. doi: 10.1042/bj2140937.
4
Phenylalkyloxirane carboxylic acids, a new class of hypoglycaemic substances: hypoglycaemic and hypoketonaemic effects of sodium 2-[5-(4-chlorophenyl)-pentyl]-oxirane-2-carboxylate (B 807-27) in fasted animals.苯烷基环氧乙烷羧酸，一类新型降血糖物质：2-[5-(4-氯苯基)-戊基]-环氧乙烷-2-羧酸钠（B 807-27）对禁食动物的降血糖和降酮血症作用
Diabetologia. 1982 Jun;22(6):456-63. doi: 10.1007/BF00282590.
5
Participation of endogenous fatty acids in the secretory activity of the pancreatic B-cell.内源性脂肪酸在胰腺β细胞分泌活动中的作用。
Biochem J. 1985 May 1;227(3):995-1002. doi: 10.1042/bj2270995.
6
Action in vivo and in vitro of 2-tetradecylglycidic acid, 2-tetradecylglycidyl-CoA and 2-tetradecylglycidylcarnitine on hepatic carnitine palmitoyltransferase.2-十四烷基缩水甘油酸、2-十四烷基缩水甘油辅酶A和2-十四烷基缩水甘油肉碱对肝脏肉碱棕榈酰转移酶的体内外作用
Biochem J. 1986 Sep 15;238(3):801-9. doi: 10.1042/bj2380801.
7
Hypoglycaemic and hypoketonaemic effects of single and repeated oral doses of methyl palmoxirate (methyl 2-tetradecylglycidate) in streptozotocin/alloxan-induced diabetic dogs.单次及重复口服棕榈氧甲酯（2-十四烷基缩水甘油酸甲酯）对链脲佐菌素/四氧嘧啶诱导的糖尿病犬的降血糖和降酮血症作用
Br J Pharmacol. 1988 May;94(1):130-6. doi: 10.1111/j.1476-5381.1988.tb11507.x.