Askanazi J, Elwyn D H, Kinney J M, Gump F E, Michelsen C B, Stinchfield F E, Fürst P, Vinnars E, Bergström J
Ann Surg. 1978 Dec;188(6):797-803. doi: 10.1097/00000658-197812000-00014.
The amino acid pattern following total hip replacement is characterized by increases in muscle of the branched chain amino acids (leucine, isoleucine and valine), the aromatics (phenylalanine and tyrosine) as well as methionine. The nonessential amino acids in muscle tend to decline, glutamine having the most marked change. Plasma levels of the essential amino acids increase while the nonessentials tend to decrease. This pattern differs from that observed in other catabolic states (uremia, starvation, untreated diabetes) and is significantly different from the effects of inactivity and starvation combined. This suggests that injury can be characterized by a unique pattern of muscle and plasma amino acids.
全髋关节置换术后的氨基酸模式特点是，支链氨基酸（亮氨酸、异亮氨酸和缬氨酸）、芳香族氨基酸（苯丙氨酸和酪氨酸）以及蛋氨酸在肌肉中的含量增加。肌肉中的非必需氨基酸往往会减少，谷氨酰胺的变化最为显著。必需氨基酸的血浆水平升高，而非必需氨基酸的血浆水平往往会降低。这种模式不同于在其他分解代谢状态（尿毒症、饥饿、未经治疗的糖尿病）中观察到的模式，并且与不活动和饥饿共同作用的影响有显著差异。这表明损伤可以通过肌肉和血浆氨基酸的独特模式来表征。
