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荧光素二月桂酸酯用于诊断囊性纤维化患者的胰腺功能不全(作者译)

[Diagnosis of pancreatic insufficiency with fluorescein dilaurate in patients with cystic fibrosis (author's transl)].

作者信息

Schönberger W, Weitzel D

出版信息

Monatsschr Kinderheilkd (1902). 1980 Apr;128(4):195-8.

PMID:7366590
Abstract

The tubeless pancreas-function test with fluorescein dilaurate, which is based on the saponification of the test substance by pancreas-specific arylesterases, and which has proved itself in adults, was given to children for the first time. After reduction of the size of the test dose and the amount of liquid to be drunk, there were no difficulties in carrying out the test. Elimination of the fluorescein released from the flourescein dilaurate and excreted via the kidneys was clearly less in patients with cystic fibrosis than in normal subjects. Thus, the test in its modified form for children can provide adequate differentiation between normal and pathological pancreas function.

摘要

基于胰腺特异性芳基酯酶对测试物质进行皂化反应的荧光素二月桂酸酯无管胰腺功能测试,在成人中已得到验证,此次首次应用于儿童。在减少测试剂量和饮水量后,该测试的实施没有困难。囊性纤维化患者从荧光素二月桂酸酯释放并经肾脏排泄的荧光素的消除明显少于正常受试者。因此,改良后的儿童测试能够充分区分正常和病理性胰腺功能。

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