雄性大鼠接受类固醇治疗后的内分泌学和生理学特征。
Endocrinological and physiological features after steroid treatment of male rats.
作者信息
Hunt D M, Lau I F, Saksena S K, Chang M C
出版信息
Arch Androl. 1978 Sep;1(4):311-20. doi: 10.3109/01485017808988351.
The effects of medroxyprogesterone acetate (Provera), testosterone propionate (TP), ethinyl estradiol (EE), and ethynodiol diacetate (ED) treatments on sperm population in different segments of the male rat reproductive tract, reproductive organ weights, circulating androgens and fertility were studied. Ten microgram TP given for five days reduced the sperm population and organ weights. A marked reduction in the number of sperm and reproductive organ weights was observed in males orally treated with estrogens. Only long-term (20 days) treatment with Provera (1 mg/day) significantly reduced sperm population and reproductive organ weights. Combination of TP and Provera resulted in a more pronounced reduction in sperm counts and organ weights. Among steroids studied, estrogen was the only compound which suppressed fertility and circulating steroid levels.
研究了醋酸甲羟孕酮（安宫黄体酮）、丙酸睾酮（TP）、炔雌醇（EE）和双醋炔诺醇（ED）对雄性大鼠生殖道不同节段精子数量、生殖器官重量、循环雄激素水平及生育力的影响。连续五天给予10微克TP可降低精子数量和器官重量。口服雌激素的雄性大鼠精子数量和生殖器官重量显著降低。仅长期（20天）给予安宫黄体酮（1毫克/天）可显著降低精子数量和生殖器官重量。TP与安宫黄体酮联合使用可使精子计数和器官重量更显著降低。在所研究的类固醇中，雌激素是唯一能抑制生育力和循环类固醇水平的化合物。
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