Choulot J J, Saint-Martin J
Nouv Presse Med. 1980 Feb 16;9(8):515-7.
A 17-year-old patient with insulin-dependent diabetes since the age of 2 developed limitation in the range of joint movements (wrist, interphalangeal, metacarpophalangeal, elbows, knees) which progressively worsened. It is important to seek such articular complications which would seem to be common and probably underestimated in terms of their importance regarding the professional future of these patients. Associated dwarfism (as seen in our own patient) would seem to be rare. The aetiopathogenesis remains hypothetical. It is only by verification of these hypotheses, in particular that of the possibility of increased polymerisation of collagen, that therapeutic deductions (d-penicillamine) may be envisaged.
一名自2岁起就患有胰岛素依赖型糖尿病的17岁患者,出现了关节活动范围受限(手腕、指间、掌指、肘部、膝盖),且病情逐渐恶化。重要的是要寻找这类关节并发症,它们似乎很常见,而且就这些患者的职业前景而言,其重要性可能被低估了。相关的侏儒症(如我们自己的患者所见)似乎很罕见。病因发病机制仍然是假设性的。只有通过验证这些假设,特别是胶原蛋白聚合增加的可能性这一假设,才可以设想出治疗推论(d-青霉胺)。