Cooper S J, McClelland A
Pharmacol Biochem Behav. 1980 Jan;12(1):23-8. doi: 10.1016/0091-3057(80)90410-4.
Chlordiazepoxide (5, 10 mg/kg) increased the time devoted to eating familiar laboratory chow without altering the response to a range of novel, palatable foods which were also available to the food-deprived rats. Prior experience with the same range of alternative foods (food familiarization) radically changed the effect of the drug. After familiarization with these foods, chow was virtually ignored as a food choice, indicating its low relative palatability; chlordiazepoxide then prolonged the time eating the familiarized foods without significantly increasing the response to chow. These results are not consistent with an anti-food neophobia action of chordiazepoxide. They suggest instead that chlordiazepoxide enhances feeding responses related to food saliency. Footshock, delivered two days before the food choice test affected performance within the test. Its effects were opposite those of chlordiazepoxide, but they competed additively with the drug's effects. These results indicate that chlordiazepoxide's action was not simply to remove any inhibitory effect on feeding produced by fear; instead the drug promoted approach to food antagonizing any deficit in approach associated with fear. These findings are viewed as consistent with an action of chlordiazepoxide to augment the level of feeding motivation. Chlordiazepoxide (15 mg/kg) may act to overcome food neophobia.
氯氮䓬（5、10毫克/千克）增加了食用熟悉的实验室食物所花费的时间，同时并未改变对一系列新颖可口食物的反应，这些食物同样可供饥饿的大鼠食用。对相同范围的替代食物有过先前经验（食物熟悉化）后，药物的效果发生了根本改变。熟悉这些食物后，大鼠几乎不再选择实验室食物，这表明其相对适口性较低；氯氮䓬随后延长了食用熟悉食物的时间，但并未显著增加对实验室食物的反应。这些结果与氯氮䓬具有抗食物新恐惧症作用不一致。相反，它们表明氯氮䓬增强了与食物显著性相关的进食反应。在食物选择测试前两天施加的足底电击影响了测试中的表现。其效果与氯氮䓬相反，但与药物的效果呈累加性竞争。这些结果表明，氯氮䓬的作用并非简单地消除恐惧对进食产生的任何抑制作用；相反，该药物促进了对食物的趋近行为，对抗了与恐惧相关的趋近行为缺陷。这些发现被认为与氯氮䓬增强进食动机水平的作用一致。氯氮䓬（15毫克/千克）可能起到克服食物新恐惧症的作用。
