Brinch L, Teisberg P, Fausa O, Akesson I
Scand J Gastroenterol. 1980;15(1):33-8. doi: 10.3109/00365528009181428.
To study possible pathogenetic mechanisms in adult coeliac disease, we performed a metabolic investigation of a component (C3) of the most important effector of humoral immunity, the complement system. Purified and biologically active C3 was labelled with 125I and injected together with 131I-labelled albumin into six patients with adult coeliac disease exhibiting different degrees of disease activity. The same labelled preparations were given to 12 normal individuals. Plasma and urine radioactivity were studied for a total of 8 days. Fractional catabolic rates (FCR) and synthesis rates were calculated by the metabolic clearance method. Other mathematical methods were not used because a final straight exponential was not always obtained, probably owing to extravascular sequestration of protein. An increased FCR was found in most patients, with the highest values seen in active, untreated disease. This suggests that activation of complement by immune complexes may be a pathogenetic factor in adult coeliac disease.
为研究成人乳糜泻可能的发病机制，我们对体液免疫最重要的效应物补体系统的一个成分（C3）进行了代谢研究。将纯化且具有生物活性的C3用125I标记，并与131I标记的白蛋白一起注入6例患有不同疾病活动程度的成人乳糜泻患者体内。将相同的标记制剂给予12名正常个体。对血浆和尿液放射性进行了总共8天的研究。通过代谢清除法计算分解代谢率（FCR）和合成率。未使用其他数学方法，因为可能由于蛋白质的血管外隔离，并非总能得到最终的直线指数。大多数患者的FCR升高，在活动期、未治疗的疾病中值最高。这表明免疫复合物激活补体可能是成人乳糜泻的一个发病因素。
