强直性脊柱炎中C3的体内代谢
The in-vivo metabolism of C3 in ankylosing spondylitis.
作者信息
Brinch L, Vinje O, Teisberg P, Mellbye O J, Aakesson I
出版信息
Ann Rheum Dis. 1982 Feb;41(1):86-9. doi: 10.1136/ard.41.1.86.
Abstract
Turnover studies with radioactively labelled C3 were performed in 7 patients with ankylosing spondylitis and in 14 healthy individuals . As a group the patients had a moderately higher fractional catabolic rate of C3 than the controls. A possible explanation is that the complement system is activated by immune complexes. The serum levels of C3 were high. The hypercatabolism was therefore more than compensated for by an increased synthesis rate.
摘要
对7例强直性脊柱炎患者和14名健康个体进行了用放射性标记C3的周转率研究。作为一个群体，患者的C3分解代谢率分数略高于对照组。一种可能的解释是补体系统被免疫复合物激活。C3的血清水平很高。因此，合成率的增加足以弥补高分解代谢。
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