一名浆细胞白血病患者存在两种易位，即t(11;14)和t(1;6)，以及两群浆细胞。

2 translocations, t(11;14) and t(1;6), in a patient with plasma cell leukaemia and 2 populations of plasma cells.

作者信息

Gahrton G, Zech L, Nillsson K, Lönnqvist B, Carlström A

出版信息

Scand J Haematol. 1980 Jan;24(1):42-6. doi: 10.1111/j.1600-0609.1980.tb01315.x.

DOI:10.1111/j.1600-0609.1980.tb01315.x

Abstract

2 translocations, t(11;14) and t(1;6), were found in 24 out of 46 metaphases in bone marrow cells from an untreated patient with plasma cell leukaemia. The predominating cell population produced only kappa chains while a minute population produced IgG kappa. All serum Ig's were low and only minimal amounts of monoclonal IgG kappa were found in the serum and very small amounts of kappa light chains in the urine. Analyses of ours and 2 other reported patients indicated the possibility that the location of breakpoints on the chromosomes may be of etiologic importance for the type of light chain and perhaps for the class of heavy chain.

摘要

在一名未经治疗的浆细胞白血病患者的骨髓细胞的46个中期分裂相中，有24个发现了两种易位，即t(11;14)和t(1;6)。主要细胞群体仅产生κ链，而少量群体产生IgG κ。所有血清免疫球蛋白水平都很低，血清中仅发现极少量的单克隆IgG κ，尿液中仅发现极少量的κ轻链。对我们以及另外2例已报道患者的分析表明，染色体上断点的位置可能对轻链类型甚至重链类别具有病因学意义。