Quail M, Karelse R H
S Afr Med J. 1980 Apr 5;57(14):551-2.
Disulfiram (Antabuse) is used extensively in the management of alcoholism and, although mild psychiatric symptoms are quite common side-effects of treatment with this drug, psychotic reactions rarely occur. With the high doses of disulfiram used in earlier days, the incidence of 'psychosis' was estimated at 2 - 20%. A more recent review suggests that the incidence is far lower and that the 'psychosis' described in many cases consisted of mild psychiatric disturbances, such as anxiety and sedation, as well as a more florid psychosis or an organic brain syndrome. Of the 52 cases reported in the English-language literature, only 9 reflect psychotic reactions to disulfiram, the remainder being schizophrenic or developing a picture of organic brain syndrome. We report a case because of its implications.
双硫仑（戒酒硫）被广泛用于酒精中毒的治疗，尽管轻度精神症状是使用该药治疗时相当常见的副作用，但很少发生精神反应。在早期使用高剂量双硫仑时，“精神病”的发生率估计为2%至20%。最近的一项综述表明，发生率要低得多，而且许多病例中所描述的“精神病”包括轻度精神障碍，如焦虑和镇静，以及更明显的精神病或器质性脑综合征。在英文文献报道的52例病例中，只有9例反映了对双硫仑的精神反应，其余为精神分裂症或呈现器质性脑综合征的症状。我们报告1例病例，因其具有启示意义。
