[Effect of pyridoxal phosphate and pantothenate derivatives on gamma-aminobutyric shunt in the brain of mice].

Repeated administration of D-pantothenate Ca, D-homopantothenate Ca and pantethine at a dose of 150 mmole/kg of body weight (9 injections within 3 days) led to alterations in activity of GABA-shunt enzymes as well as in content of free amino acids in mouse brain. These alterations suggest that B3-vitamin preparations potentiate the regulating effect on gamma-aminobutyrate pathway, which shunts the alpha-ketoglutarate dehydrogenase reaction, depending on CoA content. The most distinct but short-term intesification of the GABA-shung was observed in treatment with homopantothenate containing GABA molecule. Pantothenate and pantethine caused similar alterations, consisting in activation of GABA production and in inhibition of its utilization; in this case pantethine was less effective. Pyridoxal phosphate activated GABA-shunt; this resulted in accelerated decrease in content of dicarboxylic amino acids and their amides.