Frisk-Holmberg M
Acta Med Scand. 1980;207(1-2):43-5. doi: 10.1111/j.0954-6820.1980.tb09673.x.
The therapeutic efficacy of clonidine as an antihypertensive in a b.i.d. schedule 150--300 micrograms daily was evaluated. The blood pressure reduction in patients with essential hypertension was satisfactory on this regimen and the steady-state plasma concentrations were within the BP-lowering concentration range at the end of a dosage interval.
评估了可乐定作为抗高血压药物每日两次、每次150 - 300微克给药方案的治疗效果。在该治疗方案下,原发性高血压患者的血压降低效果令人满意,且在一个给药间隔结束时,稳态血浆浓度处于降压浓度范围内。