可乐定-氯噻酮联合用药每日一次和每日两次治疗原发性高血压
Clonidine-chlorthalidone combination once and twice daily in essential hypertension.
作者信息
Noveck R J, McMahon F G, Jain A K, Ryan J R
出版信息
Clin Pharmacol Ther. 1980 Nov;28(5):581-6. doi: 10.1038/clpt.1980.206.
PMID:7438676
Abstract
The antihypertensive effects of a clonidine-chlorthalidone combination (Combipres) as a single daily dose at bedtime and the same amount in twice-daily doses were compared in an open-label, crossover study in 14 patients. An analysis of the blood pressure and pulse data in nine patients who completed the study revealed no statistically significant differences between the two regimens, and no difference in the incidence of side effects was noted.
摘要
在一项针对14名患者的开放标签交叉研究中，比较了可乐定 - 氢氯噻嗪组合制剂（复方降压平）每日睡前单次给药与相同剂量分两次给药的降压效果。对完成研究的9名患者的血压和脉搏数据进行分析后发现，两种给药方案之间在统计学上无显著差异，且副作用发生率也无差异。
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Clonidine-chlorthalidone combination once and twice daily in essential hypertension.可乐定-氯噻酮联合用药每日一次和每日两次治疗原发性高血压
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