Lieberman A, Ruoff M, Estey E, Seidman I, Lieberman I, Wise A
Am J Med Sci. 1980 Jan-Feb;279(1):53-6. doi: 10.1097/00000441-198001000-00007.
Irreversible pulmonary interstitial fibrosis developed 36 days after a single course of BCNU (total, 400 mg) in a patient with a malignant brain tumor. The case is unique in that irreversible changes developed shortly after a single course of BCNU whereas heretofore such permanent changes have been associated only with multiple courses of the drug (2,000-4,000 mg). This suggests that individual differences in the local sensitivity of lung tissue may be as important as the dose of the drug in determining whether irreversible fibrosis will develop.
一名患有恶性脑肿瘤的患者在单次使用卡莫司汀（总量400毫克）后36天出现了不可逆的肺间质纤维化。该病例的独特之处在于，不可逆的变化在单次使用卡莫司汀后不久就出现了，而在此之前，这种永久性变化仅与多次使用该药物（2000 - 4000毫克）有关。这表明，在决定是否会发生不可逆纤维化时，肺组织局部敏感性的个体差异可能与药物剂量同样重要。
