Berecek K H, Schwertschlag U, Gross F
Am J Physiol. 1980 Mar;238(3):H287-93. doi: 10.1152/ajpheart.1980.238.3.H287.
Vascular resistance and reactivity were investigated in isolated, constant flow perfused kidneys of stroke-prone spontaneously hypertensive rats (SHRSP) and age- and sex-matched normotensive Wistar-Kyoto control rats (WKY rats). Stroke-prone spontaneously hypertensive rats were studied at 4 wk, 2 mo, and 4 mo of age representing different stages of development of hypertension. Resistance in maximally vasodilated vascular beds was greater and the pressure-flow relationship was significantly shifted to the left in kidneys of SHRSP as compared to WKY rats. Responses to norepinephrine, vasopressin, serotonin, and angiotensin II were enhanced in the renal vascular bed of SHRSP. Dose-response curves were shifted to the left, had steeper slopes, decreased thresholds, and increased maximal responses. With longer duration of hypertension, resistance increased, the slopes of the dose-response curves were steeper, and maximum responses greater. The higher resistance and enhanced reactivity in the renal vasculature of SHRSP, already demonstrable in the prehypertensive stage appear to be due to primary structural and functional alterations of the resistance vessels.
在易患中风的自发性高血压大鼠（SHRSP）以及年龄和性别匹配的正常血压Wistar-Kyoto对照大鼠（WKY大鼠）的离体、恒流灌注肾脏中，研究了血管阻力和反应性。对易患中风的自发性高血压大鼠在4周龄、2月龄和4月龄时进行研究，这些年龄段代表了高血压发展的不同阶段。与WKY大鼠相比，SHRSP肾脏中最大程度血管舒张的血管床的阻力更大，压力-流量关系显著向左偏移。在SHRSP的肾血管床中，对去甲肾上腺素、血管加压素、5-羟色胺和血管紧张素II的反应增强。剂量-反应曲线向左偏移，斜率更陡，阈值降低，最大反应增加。随着高血压持续时间延长，阻力增加，剂量-反应曲线的斜率更陡，最大反应更大。在高血压前期就已表现出的SHRSP肾血管系统中较高的阻力和增强的反应性，似乎是由于阻力血管的原发性结构和功能改变所致。
