Lu H H, Kou I L, Chen Y M
Chin J Physiol. 1978;22(4):171-9.
By means of an isolated kidney perfusion technique, reactivities of renal body vessels to electrical stimulation of renal plexus and intravascular administrations of low dosed norepinephrine and epinephrine were determined in the spontaneously hypertensive rats of Wistar strain, normotensive Sprague-Dawley rats and Sprague-dawley rats with renal hypertension of the same sex and as equal as possible with respect to age and body weight. The basal vascular resistance as indicated by the perfusion pressure caused by the same rat of perfusion was significantly higher in the renal hypertensive group. Both electrical stimulation of the renal plexus and intravascular administrations of catecholamines caused a rise of perfusion pressure. Analysis of the dose-response relationship reveals that in the dose range used, the sensitivities to electrical stimulation and to norepinephrine are significantly higher in the normotensive than the hypertensive groups. The results indicate that structural change in the blood vessels is more important than the adrenergic actions of low intensity in the cause of high resistance of blood flow in hypertensive subjects at least in the kidney.
采用离体肾脏灌注技术，在Wistar品系自发性高血压大鼠、正常血压的Sprague-Dawley大鼠以及同龄、体重尽可能相近的同性肾性高血压Sprague-Dawley大鼠中，测定了肾体血管对肾丛电刺激以及低剂量去甲肾上腺素和肾上腺素血管内给药的反应性。由同一只大鼠进行灌注所产生的灌注压所指示的基础血管阻力，在肾性高血压组中显著更高。肾丛电刺激和儿茶酚胺血管内给药均导致灌注压升高。剂量-反应关系分析表明，在所使用的剂量范围内，正常血压组对电刺激和去甲肾上腺素的敏感性显著高于高血压组。结果表明，至少在肾脏中，血管结构变化在高血压患者高血流阻力成因中比低强度肾上腺素能作用更为重要。
