Abrams J S
Am J Surg. 1980 Apr;139(4):539-43. doi: 10.1016/0002-9610(80)90334-7.
The gross and microscopic pathologic features of 167 rectal cancers were reviewed and the size, morphology and degree of differentiation correlated with the histologic Dukes' classification. A diagnosis of Dukes' A adenocarcinoma was made in 32 percent of all rectal cancers and in 70 percent of nonulcerated partly or well differentiated cancers that did not exceed 5 cm in greatest diameter. The incidence of Dukes' A lesions in patients meeting these criteria is similar to the survival rates reported after local excision, electrocoagulation and endorectal radiation. A prospective study comparing the results of local treatment with radical resection in selected patients is recommended.
回顾了167例直肠癌的大体和显微镜下病理特征，并将其大小、形态及分化程度与组织学Dukes分期进行了关联分析。在所有直肠癌中，32%被诊断为Dukes A期腺癌，在直径最大不超过5cm的非溃疡性部分或高分化癌中，这一比例为70%。符合这些标准的患者中Dukes A期病变的发生率与局部切除、电凝及直肠内放疗后报告的生存率相似。建议进行一项前瞻性研究，比较在特定患者中局部治疗与根治性切除的结果。
