草酸盐作为二氯乙酸的一种分解代谢产物的特性，该分解代谢产物负责抑制大鼠肝细胞中的糖异生和丙酮酸羧化作用。 - Suppr | 超能文献

Characterization of oxalate as a catabolite of dichloroacetate responsible for the inhibition of gluconeogenesis and pyruvate carboxylation in rat liver cells.

作者信息

Demaugre F, Cepanec C, Leroux J P

出版信息

Biochem Biophys Res Commun. 1978 Dec 14;85(3):1180-5. doi: 10.1016/0006-291x(78)90666-6.

DOI:10.1016/0006-291x(78)90666-6

Abstract

摘要

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1

Characterization of oxalate as a catabolite of dichloroacetate responsible for the inhibition of gluconeogenesis and pyruvate carboxylation in rat liver cells.草酸盐作为二氯乙酸的一种分解代谢产物的特性，该分解代谢产物负责抑制大鼠肝细胞中的糖异生和丙酮酸羧化作用。

Biochem Biophys Res Commun. 1978 Dec 14;85(3):1180-5. doi: 10.1016/0006-291x(78)90666-6.

2

Mechanism responsible for the hypoglycemic actions of dichloroacetate and 2-chloropropionate.二氯乙酸和2-氯丙酸降血糖作用的机制。

Arch Biochem Biophys. 1979 Nov;198(1):145-52. doi: 10.1016/0003-9861(79)90405-3.

3

Comparison of the effects of 2-chloropropionate and dichloroacetate on ketogenesis and lipogenesis in isolated rat hepatocytes.2-氯丙酸酯和二氯乙酸对分离的大鼠肝细胞生酮作用和脂肪生成作用的效果比较。

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4

Inhibition of hepatic gluconeogenesis by dichloroacetate.二氯乙酸对肝糖异生的抑制作用。

Arch Biochem Biophys. 1978 Aug;189(2):364-71. doi: 10.1016/0003-9861(78)90223-0.

5

Studies on the inhibition of gluconeogenesis by oxalate.草酸盐对糖异生作用抑制的研究。

Biochim Biophys Acta. 1980 Nov 17;633(1):122-33. doi: 10.1016/0304-4165(80)90044-6.

6

Effects of oxalate and dichloroacetate on lipogenesis and ketogenesis in rat hepatocytes.

Biochem Biophys Res Commun. 1982 Feb 11;104(3):1107-13. doi: 10.1016/0006-291x(82)91364-x.

7

Inhibition of lactate glucogneogenesis in rat kidney by dichloroacetate.二氯乙酸对大鼠肾脏中乳酸糖异生的抑制作用。

Biochem J. 1978 Mar 15;170(3):551-60. doi: 10.1042/bj1700551.

8

Metabolic effects of dichloroacetate.二氯乙酸的代谢效应。

N Engl J Med. 1978 Aug 3;299(5):255-6. doi: 10.1056/nejm197808032990515.

9

The effects of pyruvate concentration, dichloroacetate and alpha-cyano-4-hydroxycinnamate on gluconeogenesis, ketogenesis and [3-hydroxybutyrate]/[3-oxobutyrate] ratios in isolated rat hepatocytes.丙酮酸浓度、二氯乙酸和α-氰基-4-羟基肉桂酸对分离的大鼠肝细胞糖异生、酮体生成及[3-羟基丁酸]/[3-氧代丁酸]比值的影响。

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Effect of dichloroacetate on gluconeogenesis in vivo in the presence of a fixed gluconeogenic substrate supply to the liver.在向肝脏提供固定糖异生底物的情况下，二氯乙酸对体内糖异生的影响。

Metabolism. 1981 Sep;30(9):880-5. doi: 10.1016/0026-0495(81)90066-4.

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The rôle of mitochondrial pyruvate transport in the stimulation by glucagon and phenylephrine of gluconeogenesis from L-lactate in isolated rat hepatocytes.线粒体丙酮酸转运在胰高血糖素和去氧肾上腺素刺激离体大鼠肝细胞由L-乳酸进行糖异生过程中的作用。

Biochem J. 1981 Sep 15;198(3):551-60. doi: 10.1042/bj1980551.

2

Regulation of rat liver hydroxymethylglutaryl coenzyme A reductase by a new class of noncompetitive inhibitors. Effects of dichloroacetate and related carboxylic acids on enzyme activity.新型非竞争性抑制剂对大鼠肝脏羟甲基戊二酰辅酶A还原酶的调节作用。二氯乙酸及相关羧酸对酶活性的影响。

J Clin Invest. 1983 Nov;72(5):1575-85. doi: 10.1172/JCI111116.

3

Treatment of chronic congenital lactic acidosis by oral administration of dichloroacetate.口服二氯乙酸治疗慢性先天性乳酸性酸中毒。

J Inherit Metab Dis. 1986;9(3):244-52. doi: 10.1007/BF01799655.