Rice G P, Boughner D R, Stiller C, Ebers G C
Ann Neurol. 1980 Feb;7(2):130-4. doi: 10.1002/ana.410070207.
In a 27-member family, 8 individuals had mitral valve prolapse (MVP) by echocardiography. Four of them suffered a total of eight cerebral ischemic events in the first four decades of life. In none of these patients could risk factors for stroke, other than MVP, be found. Stroke did not occur in individuals free of MVP. This report draws attention to a previously unrecognized cause of familial stroke which strengthens the relationship between MVP and premature stroke.
在一个27人的家族中，经超声心动图检查发现8人有二尖瓣脱垂（MVP）。其中4人在生命的前40年共发生了8次脑缺血事件。在这些患者中，除MVP外，未发现其他中风危险因素。无MVP的个体未发生中风。本报告提请注意一种先前未被认识的家族性中风病因，这加强了MVP与早发性中风之间的关系。
