Spence J D, Wong D G, Melendez L J, Nichol P M, Brown J D
Can Med Assoc J. 1984 Dec 15;131(12):1457-60.
Patients with classic migraine (69 women and 31 men) selected randomly from a practice list of over 1000 were matched for age, sex and neighbourhood with 100 people who did not have headache problems, and both groups underwent M-mode and two-dimensional echocardiography and clinical examination by cardiologists blinded to the subjects' clinical status. The mean ages were 34.9 +/- 11.3 years for the migraine group and 33.1 +/- 9.9 years for the control group. Definite and possible mitral valve prolapse (MVP), diagnosed according to predefined echocardiographic criteria, were found about twice as often in the migraine group as in the control group (in 15 v. 7 and 16 v. 8 patients respectively); the echocardiograms were definitely normal in 69 migraine patients and 85 controls (chi 2 = 8.39, p less than 0.025). Altogether 25% of the migraine group and 11% of the control group had evidence of MVP from a combination of the echocardiographic and auscultatory findings (chi 2 = 5.72, p less than 0.025). The odds ratio was 2.7, with 95% confidence limits of 1.17 and 6.29. The association between migraine and MVP has implications for the understanding of platelet abnormalities and episodes of cerebral ischemia occurring in both these conditions.
从1000多名患者的病历列表中随机选取69名女性和31名男性的典型偏头痛患者，将其与100名无头痛问题的人按年龄、性别和居住区域进行匹配。两组均接受了M型和二维超声心动图检查，并由对受试者临床状况不知情的心脏病专家进行临床检查。偏头痛组的平均年龄为34.9±11.3岁，对照组为33.1±9.9岁。根据预定义的超声心动图标准诊断出的明确和可能的二尖瓣脱垂（MVP），在偏头痛组中的发现频率约为对照组的两倍（分别为15例对7例和16例对8例）；69例偏头痛患者和85例对照的超声心动图结果完全正常（χ2 = 8.39，p < 0.025）。综合超声心动图和听诊结果，偏头痛组中有25%的人有MVP证据，对照组为11%（χ2 = 5.72，p < 0.025）。优势比为2.7，95%置信区间为1.17至6.29。偏头痛与MVP之间的关联对于理解这两种情况下发生的血小板异常和脑缺血发作具有重要意义。
