Robinson J K, Baughman R D, Auerbach R, Cimis R J
Arch Dermatol. 1980 Apr;116(4):413-5. doi: 10.1001/archderm.116.4.413.
Fibrosis of the liver developed to a degree that contraindicated further treatment with methotrexate in 11 of 43 patients who had been receiving maintenance therapy with methotrexate for psoriasis. Liver biopsy had been performed prior to initiation of methotrexate therapy and was repeated at 12- to 18-month intervals. In this retrospective study, age of the patient and duration of therapy have been found to be significant factors in those patients receiving only the weekly oral dosage schedule. Yearly biopsies of the liver are recommended for patients who receive methotrexate throughout their courses of therapy.
在43例接受甲氨蝶呤维持治疗银屑病的患者中，有11例出现了肝脏纤维化，其程度已达到不宜继续使用甲氨蝶呤治疗的指征。在开始甲氨蝶呤治疗前已进行肝脏活检，并每隔12至18个月重复一次。在这项回顾性研究中，发现患者年龄和治疗持续时间是仅接受每周口服给药方案的患者的重要影响因素。建议在整个治疗过程中接受甲氨蝶呤治疗的患者每年进行肝脏活检。
