Schleicher S M, Fricker M P
Arch Dermatol. 1980 Apr;116(4):444-5.
Necrosis of the skin developed soon after the initiation of coumarin therapy in an elderly woman. Inadvertent rechallenge resulted in similar lesions. Coumarin necrosis is a poorly understood phenomenon unlikely to respond to therapy. Fortunately, its incidence is quite rare, considering the widespread use of this anticoagulant.
一位老年女性在开始使用香豆素治疗后不久出现了皮肤坏死。意外再次使用导致了类似的病变。香豆素坏死是一种了解甚少的现象,不太可能对治疗产生反应。幸运的是,考虑到这种抗凝剂的广泛使用,其发生率相当罕见。