Chandra S V, Shukla G S, Srivastava R S, Gupta S K
Arch Environ Contam Toxicol. 1980;9(1):79-85. doi: 10.1007/BF01055501.
The toxic effects of manganese in combination with iron or copper on the brain tissue of mice were investigated. The combined administration of manganese and iron decreased the accumulation of manganese in the brain compared to manganese treatment alone. This indicated that excess iron may influence the absorption of manganese. Combined exposure to manganese and copper resulted in marked accumulation of copper in the brain. This is of great concern, since excess copper in brain produces incoordination in body movements. Thus, the combined exposure of these two metals, even in permissible limits, may produce serious brain dysfunctions. The combined administration of manganese with iron or copper has also significantly altered the levels of brain tryptophan and 5-hydroxytryptamine.
研究了锰与铁或铜联合作用对小鼠脑组织的毒性影响。与单独给予锰相比，锰与铁联合给药可降低脑中锰的蓄积。这表明过量的铁可能会影响锰的吸收。锰与铜联合暴露导致脑中铜明显蓄积。这令人十分担忧，因为脑中过量的铜会导致身体运动不协调。因此，即使这两种金属的联合暴露在允许范围内，也可能产生严重的脑功能障碍。锰与铁或铜联合给药还显著改变了脑中色氨酸和5-羟色胺的水平。
