Shukla A, Agarwal K N, Shukla G S
Department of Pediatrics, Banaras Hindu University, Varanasi, India.
Experientia. 1990 Jul 15;46(7):751-2. doi: 10.1007/BF01939956.
Feeding a marginally low iron content diet (18-20 mg iron/kg diet) to weaned (21-day-old) rats for 8 weeks produced a significant decrease in liver non-heme iron (66%, p less than 0.001) but no change in blood hemoglobin. Total iron contents of liver (56%, p less than 0.01), spleen (20%, p less than 0.05), and kidney (19%, p less than 0.05) were also found to decrease along with increased zinc, copper, calcium, manganese lead and cadmium in various organs. The magnitude of alteration of a metal was different in different organs. However, liver was found to be the most affected organ. Two weeks of rehabilitation with iron-sufficient diet (390 mg iron/kg diet) normalized these altered levels.
给断奶（21日龄）大鼠喂食边缘性低铁含量饮食（18 - 20毫克铁/千克饮食）8周，导致肝脏非血红素铁显著降低（66%，p < 0.001），但血红蛋白无变化。还发现肝脏（56%，p < 0.01）、脾脏（20%，p < 0.05）和肾脏（19%，p < 0.05）的总铁含量随着各器官中锌、铜、钙、锰、铅和镉含量的增加而降低。不同器官中金属变化的幅度不同。然而，肝脏是受影响最严重的器官。用铁充足的饮食（390毫克铁/千克饮食）进行两周的恢复治疗使这些改变的水平恢复正常。
