Taylor R G, Abresch R T, Lieberman J S, Fowler W M
Arch Phys Med Rehabil. 1980 Apr;61(4):160-6.
In vitro studies were performed on fast and slow muscles from mice to determine if secobarbital sodium (SCB) has a direct effect on muscle contractility. All preparations were curarized and stimulation was direct. After baseline studies, SCB was added to the muscle bath in 1 of 4 concentrations-10, 20, 100 and 200 microgram/ml. Tetanic tension was reduced for both muscle types at SCB concentrations greater than or equal to 20 microgram/ml, and loss was progressive with increasing dose. In contrast, twitch tension (P) was increased by SCB at the 2 higher concentrations. The increase in P was due to an increase in rate of tension development plus prolongation of the time parameter (duration) of the twitch. Fatigue was accelerated by SCB for both muscle types. The results indicate that SCB has a direct and similar effect on fast and slow skeletal muscles. The probable sites of action of the drug are the excitation contraction coupling mechanisms and the mechanisms for energy production and/or utilization.
对小鼠的快肌和慢肌进行了体外研究，以确定速可巴比妥钠（SCB）是否对肌肉收缩力有直接影响。所有标本均用箭毒处理，刺激为直接刺激。在进行基线研究后，将SCB以4种浓度之一（10、20、100和200微克/毫升）添加到肌肉浴中。当SCB浓度大于或等于20微克/毫升时，两种肌肉类型的强直张力均降低，且随着剂量增加损失逐渐加重。相比之下，在较高的两种浓度下，SCB使单收缩张力（P）增加。P的增加是由于张力发展速率增加以及单收缩时间参数（持续时间）延长。SCB加速了两种肌肉类型的疲劳。结果表明，SCB对快、慢骨骼肌有直接且相似的作用。该药物可能的作用部位是兴奋-收缩偶联机制以及能量产生和/或利用机制。
