Bodnar E, Wain W H, Martelli V, Ross D N
Artif Organs. 1980 Feb;4(1):20-3. doi: 10.1111/j.1525-1594.1980.tb03894.x.
Five hundred and eighty homograft valves have been inserted into the aortic position as isolated valve replacements, and followed up for 7--14 years. After ten years 90% of frozen homografts, 80% of autografts and 70% of freeze-dried homografts were free of valve-related death. There was only one embolism reported giving an incidence of one embolism per 143,928 patient months. Degeneration occurred in 14% of the autografts, in 30% of the freeze dried and in 60% of the frozen homografts after ten years. Eighty per cent of the fresh homografts have been free of degeneration after seven years, and 54% of freeze-dried valves have been free of degeneration after 14 years. Long-term performance of homograft and autograft valves in the aortic positon is comparable to that of any prosthetic or bioprosthetic valve. In addition, they are non-thrombogenic and excellent in terms of patient survival.
580个同种异体移植瓣膜已被植入主动脉位置作为单独的瓣膜置换物，并随访了7至14年。10年后，90%的冷冻同种异体移植物、80%的自体移植物和70%的冻干同种异体移植物无瓣膜相关死亡。仅报告了1例栓塞，发生率为每143928患者月1例栓塞。10年后，14%的自体移植物、30%的冻干移植物和60%的冷冻同种异体移植物发生退变。80%的新鲜同种异体移植物在7年后无退变，54%的冻干瓣膜在14年后无退变。主动脉位置的同种异体移植物和自体移植物瓣膜的长期性能与任何人工瓣膜或生物人工瓣膜相当。此外，它们不产生血栓，对患者生存率而言效果极佳。
