Bodnar E, Wain W H, Martelli V, Ross D N
Thorac Cardiovasc Surg. 1979 Feb;27(1):31-8. doi: 10.1055/s-0028-1096215.
Homograft valves have been used at the National Heart Hospital since 1964, and autograft valves since 1967. The homografts were treated either by freeze drying, by flash freezing, or by tissue maintenance in a nutrient medium (fresh). In order to compare these three groups of homograft valves with the autograft valves some long term assessment of valve function was required. In the whole group of 580 valves there have been 40 late deaths, which is a probability of only 7% over 6 to 14 years. Homografts and autografts are therefore excellent valves in terms of patient survival. Thromboembolism, haemolysis and bleeding may be regarded as complications which do not occur with homograft and autograft valves. There was one thrombogenic episode in this group, an incidence of one per 11,994 patient years and a probability of only 0.000083 patient years. Potentially fatal hazards of late complications with homoor autograft valves decrease with time and at this time is a negligible factor. The similarity in pattern of onset of late infections and degeneration probably reflects the greater susceptibility to infection of a degenerating valve. All three groups of homografts are very similar and differ only from the excellent performance of the autograft valves.
自1964年起，国家心脏医院开始使用同种异体移植瓣膜，自1967年起开始使用自体移植瓣膜。同种异体移植瓣膜的处理方式有冻干、速冻或在营养培养基中保存（新鲜状态）。为了将这三组同种异体移植瓣膜与自体移植瓣膜进行比较，需要对瓣膜功能进行一些长期评估。在总共580个瓣膜中，有40例晚期死亡，在6至14年期间的概率仅为7%。因此，就患者生存率而言，同种异体移植瓣膜和自体移植瓣膜都是优秀的瓣膜。血栓栓塞、溶血和出血可被视为同种异体移植瓣膜和自体移植瓣膜不会出现的并发症。该组中有1次血栓形成事件，发生率为每11994患者年1次，概率仅为0.000083患者年。同种或自体移植瓣膜晚期并发症的潜在致命风险随时间降低，目前是一个可忽略不计的因素。晚期感染和退变的发病模式相似，这可能反映出退变瓣膜对感染的易感性更高。所有三组同种异体移植瓣膜非常相似，只是与自体移植瓣膜的出色性能有所不同。
