Gottlieb N L, Major J C
Arthritis Rheum. 1978 Jul-Aug;21(6):704-8. doi: 10.1002/art.1780210616.
The eyes of 11 patients with rheumatoid arthritis (RA) who received extended chrysotherapy (mean cumulative dose greater than 7 grams during a mean 6-year period) were examined biomicroscopically. Minute reddish-purple particles were seen in the cornea (corneal chrysiasis) in 5 and in the lens (lens chrysiasis) in 4 patients. Particulate deposits were absent in 11 other RA patients who had not received gold treatment. Seven crystalline lenses from 5 gold-treated patients were removed surgically because of incidental cataract formation and analyzed for gold content using neutron activation analysis. Although the mean lens gold concentration was higher in these patients than in non-gold-treated controls without RA (0.0073 microgram/grams versus 0.001 microgram/grams), the absolute gold level was markedly lower than that found in 25 diverse tissue analyzed previously. This finding is compatible with the absence of clinical gold-related lens disease or visual impairment.
对11名接受长期金疗法（平均6年期间平均累积剂量大于7克）的类风湿性关节炎（RA）患者的眼睛进行了生物显微镜检查。5名患者的角膜出现微小的红紫色颗粒（角膜金沉着症），4名患者的晶状体出现微小的红紫色颗粒（晶状体金沉着症）。11名未接受金治疗的其他RA患者未出现颗粒状沉积物。5名接受金治疗的患者的7个晶状体因意外形成白内障而被手术摘除，并使用中子活化分析对金含量进行了分析。尽管这些患者晶状体的平均金浓度高于未患RA且未接受金治疗的对照组（0.0073微克/克对0.001微克/克），但绝对金含量明显低于先前分析的25种不同组织中的含量。这一发现与无临床金相关晶状体疾病或视力损害相符。
