Fox P K, Lewis A J, Rae R M, Sim A W, Woods G F
Arzneimittelforschung. 1980;30(1):55-9.
11 beta-Hydroxy-16 alpha, 17 alpha, 21-trimethyl-pregna-1,4-diene-3,20-dione(ORG 6216) is a novel type of anti-inflammatory steroid which displays a dissociation of local from systemic effects in a range of animal models. Moreover, ORG 6216 is exceptional in that it has not shown any significant atrophogenic activity in the skin when administered either topically or intracutaneously in animal models.
11β-羟基-16α,17α,21-三甲基-孕甾-1,4-二烯-3,20-二酮（ORG 6216）是一种新型抗炎甾体，在一系列动物模型中表现出局部效应与全身效应的分离。此外，ORG 6216的特殊之处在于，在动物模型中局部或皮内给药时，它在皮肤上未表现出任何显著的致萎缩活性。
